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THE EFFECT OF CORTIN ON THE SODIUM, POTASSIUM, CHLORIDE, INORGANIC PHOSPHOROUS AND TOTAL NITROGEN BALANCE IN NORMAL SUBJECTS AND IN PATIENTS WITH ADDISON'S DISEASE1
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1937
Year
Electrolyte DisorderMetabolic SyndromeAdrenal GlandBody CompositionElectrolyte DisturbanceEarly AddisonNeurologyClinical ChemistryChronic Kidney DiseaseNormal IndividualsHealth SciencesSodium HomeostasisSevere AddisonAdrenal DiseaseEndocrinologyPotassium HomeostasisPhysiologyMetabolismMedicine
This investigation was undertaken in an effort to determine the usefulness of electrolyte and nitrogen balance studies in the diagnosis of early Addison's disease. Three classes of subjects were used in the study, normal individuals, patients with severe Addison's disease and patients who presented some of the signs and symptoms usually associated with Addison's disease. In all, the influence of cortin on these balances has been determined. Patients with Addison's disease do not lend themselves well to metabolic investigation. This fact coupled with the limited amount of potent adrenal cortical extract which has been available in the past is largely responsible for the few balance studies which have been made in this disease.