Concepedia

A Comparison of Injections of Botulinum Toxin and Topical Nitroglycerin Ointment for the Treatment of Chronic Anal Fissure

Giuseppe Brisinda, Giorgio Maria, Anna Rita Bentivoglio, Emanuele Cassetta, Daniele Gui, Alberto Albanese

New England Journal of Medicine · 1999 · 382 citations · 20 references

DOIFull text

Open access

Abstract

Although treatment with either topical nitroglycerin or botulinum toxin is effective as an alternative to surgery for patients with chronic anal fissure, botulinum toxin is the more effective nonsurgical treatment.

References

20

A randomised, prospective, double-blind, placebo-controlled trial of glyceryl trinitrate ointment in treatment of anal fissure

Jonathan N. Lund, J H Scholefield · The Lancet · 1997 · 377 citations

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Sequelae of internal sphincterotomy for chronic fissure in ano

Indru T. Khubchandani, James Reed · British journal of surgery · 1989 · 323 citations

, , +6

A Comparison of Botulinum Toxin and Saline for the Treatment of Chronic Anal Fissure

Giorgio Maria, Emanuele Cassetta, Daniele Gui et al. · New England Journal of Medicine · 1998 · 322 citations · Full text

‘Reversible chemical sphincterotomy’ by local application of glyceryl trinitrate

P B Loder, Michael A. Kamm, R J Nicholls et al. · British journal of surgery · 1994 · 251 citations

Sustained internal sphincter hypertonia in patients with chronic anal fissure

Ridzuan Farouk, G. S. Duthie, A. B. MacGregor et al. · Diseases of the Colon & Rectum · 1994 · 210 citations