Concepedia

Heavier Alkaline Earth Catalyzed Ene-yne Cyclizations: Atom-Efficient Access to Tetrahydroisoquinoline Frameworks

Stephanie Reid, Anthony G. M. Barrett, Michael S. Hill, Panayiotis A. Procopiou

Organic Letters · 2014 · 13 citations · 22 references

DOIFull text

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Concepts

Abstract

Tetrahydroisoquinoline frameworks may be accessed with 100% atom efficiency through the alkaline earth catalyzed addition of primary amines to ene-yne substrates through a sequence of intermolecular alkene and intramolecular alkyne hydroamination steps.

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