Early sign of atherosclerosis in slow coronary flow and relationship with angiotensin-converting enzyme I/D polymorphism

An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels.

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Hypertension, Healthy Subjects, Ace Genotype +20

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TIMI Frame Count

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Evidence, from combined segregation and linkage analysis, that a variant of the angiotensin I-converting enzyme (ACE) gene controls plasma ACE levels.

Laurence Tiret, Brigitte Rigat, C Breda et al. · PubMed · 1992 · 1.2K citations