Concepedia

Synthesis, in vitro assay, and molecular modeling of new piperidine derivatives having dual inhibitory potency against acetylcholinesterase and Aβ1–42 aggregation for Alzheimer’s disease therapeutics

Young Ee Kwon, Jung Yul Park, K. T. No, Jae Hong Shin, Sung Kwang Lee, Jae Soon Eun, Jae Heon Yang, Tae Yong Shin, Dae Keun Kim, Byung Sook Chae,

Bioorganic & Medicinal Chemistry · 2007 · 63 citations · 23 references

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References

23

A new and rapid colorimetric determination of acetylcholinesterase activity

George L. Ellman, K. Diane Courtney, Valentino Andres et al. · Biochemical Pharmacology · 1961 · 26.9K citations

Life Sciences, Biochemistry, Pharmacology +14

Thioflavine T interaction with synthetic Alzheimer's disease <i>β</i>‐amyloid peptides: Detection of amyloid aggregation in solution

Harry LeVine · Protein Science · 1993 · 2.2K citations · Full text

Life Sciences, Biochemistry, Biophysics +16

3D structure of Alzheimer's amyloid-β(1–42) fibrils

Thorsten Lührs, Christiane Ritter, Marc Adrian et al. · Proceedings of the National Academy of Sciences · 2005 · 2K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

A structural model for Alzheimer's β-amyloid fibrils based on experimental constraints from solid state NMR

Aneta T. Petkova, Yoshitaka Ishii, John J. Balbach et al. · Proceedings of the National Academy of Sciences · 2002 · 1.8K citations

Life Sciences, Biochemistry, Biophysics +17

Alzheimer's disease-affected brain: Presence of oligomeric Aβ ligands (ADDLs) suggests a molecular basis for reversible memory loss

Yuesong Gong, Lei Chang, Kirsten L. Viola et al. · Proceedings of the National Academy of Sciences · 2003 · 1.1K citations · Full text

Life Sciences, Neurobiology, Neuroscience +14