Journal of Natural Products · 2010 · 31 citations · 3 references
PharmacyMedicinal ChemistryPharmacologyBiochemical PharmacologyDrug DiscoveryEnzymologyBioactive Small MoleculesEnzyme InhibitionFungal Secondary MetabolitesMedicinal PlantsNatural Product Drug DiscoveryBioactive Compound LibrariesBioactive Fungal MetabolitesBioactive Plant Compounds
Three novel p-terphenyl compounds, named boletopsins A (1), B (2), and C (3), and four known analogues (4-7) were isolated from fruiting bodies of the mushroom Boletopsis leucomelas. Compounds 1-7 were tested for KDR kinase inhibitory activity, and boletopsin C (3) was found to have an IC(50) value of 70.7 microM. Compound 3 also showed inhibition of proliferation of human umbilical vein endothelial cells, with an IC(50) value of 9.04 microM.
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Cutting off cancer's supply lines
Erika Check Hayden · Nature · 2009 · 49 citations