Concepedia

Long-Term Effect of<i>N</i>-Acetyl-Seryl-Aspartyl-Lysyl-Proline on Left Ventricular Collagen Deposition in Rats With 2-Kidney, 1-Clip Hypertension

Nour-Eddine Rhaleb, Hongmei Peng, Xiao-Ping Yang, Yun-He Liu, Dharmesh Mehta, Éric Ezan, Oscar A. Carretero

Circulation · 2001 · 67 citations · 33 references

DOIFull text

Open access

Abstract

Ac-SDKP inhibited monocyte/macrophage infiltration, cell proliferation, and collagen deposition in the LV of hypertensive rats without affecting blood pressure or cardiac hypertrophy, suggesting that it may be partly responsible for the cardioprotective effect of angiotensin-converting enzyme inhibitors.

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