Abasic‐Site‐Containing Oligodeoxynucleotides as Aptamers for Riboflavin

Abstract

Finding flavins: A new class of DNA-duplex aptamers that bind to riboflavin by utilizing an abasic (AP) site has been developed (see model). An optimized duplex shows high selectivity for riboflavin over flavin mononucleotide and flavin adenine dinucleotide. Such riboflavin–duplex interactions are discussed as a basis for the further development of AP-site-based DNA aptamers.