BMJ · 1988 · 253 citations · 14 references
Life SciencesNeurosciencePharmacologyBehavioral NeuroscienceDementiaNeuropharmacologyAddictionDrug DependenceNeuromodulationNeurotransmissionReward PathwaysSynaptic TransmissionD2-like Dopamine ReceptorsDopamine D2-like ReceptorsDynorphin ModulationDynorphin NeuronsGabaergic Mechanisms Of WithdrawalGabaergic Reward SignalingInhibitory NeurotransmissionPostsynaptic Inhibition
General practitioners and community nurses were asked to rate the likelihood of dementia for each of their elderly patients. Cases of dementia were identified by research psychiatrists using the Cambridge mental disorders of the elderly examination (CAMDEX), a new structured diagnostic interview. General practitioners correctly identified dementia as at least a possibility in 121 of the 208 cases found. Nevertheless, they mistakenly rated as demented several patients suffering from functional psychiatric disorders, in particular depression. Community nurses correctly identified dementia as at least a possibility in 64 of the 74 demented patients known to them, but they incorrectly suspected dementia in a greater proportion of instances. Both general practitioners and families appeared to have low expectations of what general practice has to offer demented elderly people. General practitioners should take the initiative in diagnosing dementia in very elderly patients who show signs of the condition. In some cases it may be secondary to treatable disorders, and in others all that may be required are understanding, support, and advice to families.
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Marshal F. Folstein, Susan E. Folstein, Paul R. McHugh · Journal of Psychiatric Research · 1975 · 86.9K citations
The Meaning of Cognitive Impairment in the Elderly
Marshal F. Folstein, James C. Anthony, Irma M. Parhad et al. · Journal of the American Geriatrics Society · 1985 · 586 citations