Magnetic Resonance Microscopy Defines Ethanol‐Induced Brain Abnormalities in Prenatal Mice: Effects of Acute Insult on Gestational Day 8

Abstract

This study demonstrates that exposure to ethanol occurring in mice at stages corresponding to the human fourth week postfertilization results in structural brain abnormalities that are readily identifiable at fetal stages of development. In addition to illustrating the utility of MR microscopy for analysis of an FASD mouse model, this work provides new information that confirms and extends human clinical observations. It also provides a framework for comparison of structural brain abnormalities resulting from ethanol exposure at other developmental stages and dosages.