Preparation of <i>syn</i>-Tertiary Homoallylic Alcohols Utilizing Allenyltitanocenes Generated by Reductive Titanation of γ-Trimethylsilylpropargylic Carbonates

Abstract

syn-Tertiary homoallylic alcohols were obtained by the reaction of alpha-silylallenyltitanocenes generated by the reductive titanation of gamma-silylpropargylic carbonates with Cp(2)Ti[P(OEt)(3)](2) with ketones and following desilylation and partial hydrogenation. High diastereoselectivity was observed when aromatic and alpha,beta-unsaturated ketones were employed.