Double retrograde tracer study of the corticostriatal projections to the cat caudate nucleus

Abstract

The distribution of corticostriatal neurons projecting to the caudate nucleus was examined in the cat by retrograde fluorescent tracers. Thus, Fast Blue and Diamidino Yellow were concomitantly injected in different rostrocaudal, dorsoventral, or mediolateral sectors of the caudate nucleus. The main findings of this study are: 1) few double-labeled cells were found after two injections in different sectors of the caudate nucleus; 2) double-labeled neurons were more abundant after adjacent injections and they were mainly located in 6 alpha beta, dorsolateral prefrontal, dorsomedial prefrontal, prelimbic, anterior limbic, sylvian anterior, and rostral part of cingulate cortical areas; and 3) there were variations in the spatial organization of the corticostriatal neurons in different cortical areas projecting to various parts of the caudate nucleus.