The Effect of Progesterone on the Adrenergic Receptors of the Urethra ¹

Abstract

Summary A series of urethral pressure profile studies was performed on dogs, to investigate the effect of pre‐treatment with progesterone on the adrenergic responses. The results obtained indicate that progesterone facilitates or enhances the β‐adrenergic response. The possible mechanism by which this effect is produced is discussed. It is suggested that this modification of the adrenergic response of the urethra may partly explain the beneficial results reported in prostatic obstruction.