The effect of cigarette smoke condensate on the bronchial mucosa of dogs

Abstract

RISING incideiice of bronchogenic can-T cer, as well as the clinical, statistical, and cpiileniiological evidence of the relationship betiwen cigarette smoking and lung cancer,'.14-1s, -G M Iiave stimulated us to search for adtlit i o i i a l ( larificatioti of this complex problem.Siiit e the carcinogenicity of cigarette smoke condeirsate for the skin of mice had been proved,37 it IVM clear that studies on the application ot 1 1 1 ~ w n e substance to the bronchial mu( o s i WI c ill order.T h e cxperirriental production of progressive proliferative changes, perhaps even o f invasive carcinoma of the bronchial muct)\a with repeated applications of cigarette S I I I I ) ~C rondensa te, would naturally mengthen, or the lack of production of sucli cl1;ingo .c\-orilticertainly weaken, the already :tvirilable c\ idcnc e. T h e development of the technique oC tracheal fencstration26#2i, 29 provided an t';i\\ ; I ( re\\ to the trarheobronchial tree.This sLin-litietl communicatioii at the anterior 5urface of the neck leads to the cemical trachea and peimits the repeated insertion of a bronchoscopc.Under direct bronchoscopic vision, ttw matcrials ran be applied regularly to de4-igr1;itetl areas of the bronchial inucosa and their cifects observd.Although we began to s t l i d ) the eflect o f cigarette smoke condensate