Publication | Closed Access
Total Synthesis and Trehalase-Inhibitory Activity of Trehalostatin and Its Diastereoisomer
11
Citations
1
References
1993
Year
Molecular PharmacologyDiversity Oriented SynthesisTrehalase Inhibitor TrehalostatinBiochemistryMedicineNatural SciencesTotal SynthesisDiastereoisomeric StructuresStereoselective SynthesisChemical BiologyPharmacologyPharmaceutical ChemistryInhibitory ActivityEnantioselective SynthesisDrug DiscoveryNatural Product Synthesis
Abstract Complete synthesis of both diastereoisomeric structures, initially proposed for the trehalase inhibitor trehalostatin, and their biological assay have been carried out. The synthetic compounds were found to lack an inhibitory activity against trehalase, suggesting that the inhibitor would possess convincingly its 4′-epimeric structure later assigned for trehazolin.
| Year | Citations | |
|---|---|---|
Page 1
Page 1