Journal of Pharmaceutical Analysis · 2013 · 13 citations · 10 references
Natural SciencesMedicinal ChemistryPharmaceutical AnalysisAnalytical ChemistryFood AnalysisMass Spectrometric AnalysisBioanalytical ChemistryBioanalytical Method ValidationChromatographyInstrumental AnalysisLiquid ChromatographyMass SpectrometryAccelerated Solvent ExtractionElectrospray IonizationLiquid Chromatography-mass SpectrometryLiquid Chromatography-mass Spectrometry AnalysisMultiple Reaction MonitoringTime-of-flight Mass SpectrometryUltra-performance Liquid Chromatography Method DevelopmentUltra-performance Liquid Chromatography-mass Spectrometry
An ultra-performance liquid chromatography quadrupole time of flight mass spectrometry (UPLC-qTOF-MS/MS) method was developed and validated for the simultaneous determination of glycyrrhizin and glycyrrhetic acid. These analytes were separated on a reverse phase C18 column using a mobile phase of acetonitrile:2% acetic acid in water (75:25, v/v) with a flow rate of 200 μL/min. The qTOF-MS was operated under multiple reaction monitoring (MRM) mode using the electrospray ionization (ESI) technique with positive ion polarity. A comparison of three different extraction techniques i.e. accelerated solvent extraction (ASE), extraction under ultrasonic waves (USW) and the classical extraction by percolation (CE) method was done and quantification of these extracts was also carried out by the proposed method.
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The long term efficacy of glycyrrhizin in chronic hepatitis C patients
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