Identification of a new non‐major histocompatibility complex genetic locus on chromosome 2 that controls disease severity in collagen‐induced arthritis in rats

Abstract

Sex chromosomes and Cia7 play an important role in regulating CIA in response to RII. This rat model should facilitate positional cloning and functional characterization of regulatory genes that may play a role in several forms of autoimmune disease, including rheumatoid arthritis.