ALLOGENEIC BONE MARROW TRANSPLANTATION IN A PATIENT WITH APLASTIC ANEMIA USING A PHENOTYPICALLY HL-A-IDENTICAL UNRELATED DONOR

Abstract

SUMMARY A case of an 18-year-old man with acquired aplastic anemia grafted with phenotypically HL-A-identical unrelated bone marrow after conditioning with antilymphocyte globulin (ALG) is presented. The value of random HL-A-compatible platelets in the postgrafting management is clearly documented. The failure of the marrow to take is discussed and the importance of previous sensitization with multiple transfusions and the potential role of a primary defect in the marrow matrix, failure of the humoral regulation of the hemopoiesis, and the importance of the quality of the ALG used for conditioning are emphasized.