Impaired Glucose Tolerance and Insulin Resistance in Survivors of Childhood Acute Lymphoblastic Leukemia: Prevalence and Risk Factors

Abstract

Existing evidence suggests that older age is an independent risk factor for developing IGT and IR in childhood ALL survivors, emphasizing the need for life-long metabolic screening. The PAX4 variant might impact individual susceptibility against IGT and diabetes. However, an identification of underlying risk(s) is the rational for future studies.