Increased Gastric Acid Secretion in Cholecystokinin-1 Receptor-Deficient Otsuka Long-Evans Tokushima Fatty Rats

Abstract

These results in the CCK-1 receptor-deficient OLETF rats confirmed that CCK stimulates acid secretion by binding to CCK-2 receptors, but at the same time inhibits acid responses by stimulating the paracrine secretion of somatostatin from D cells in the gastric mucosa.