The Journal of Pathology · 1996 · 75 citations · 31 references
MedicineOncologyPathologyMolecular OncologyNeoplasiaOncogenesBreast CytologyBreast PathologyEndocrine Tumor PathologyImmunohistochemistryMammary TumorsTumor MarkersAntibodiesEstrogen Receptor StatusHormone Receptor - Positive Breast CancerIntermediate Filament-associated ProteinsKi-67 ImmunostainingKi-67 Labeling IndexMalignant Breast TumorsProgesterone Receptor Status
The expression of intermediate filament proteins (IFPs) in 65 primary breast carcinomas was analysed by a panel of specific antibodies. Results were integrated with the oestrogen and progesterone receptor (ER and PGR) status, Ki-67 marking, and epidermal growth factor receptor (EGFr) expression. Invasive breast carcinomas could be divided into three main groups: group 1 revealed positivity only for 'simple epithelial' cytokeratins (CKs 7, 8, 18, and 19); group 2 also stained with the antibodies K8.12 and 34 beta E12; while group 3 showed co-expression of CKs 14 and 17, vimentin, and alpha-smooth muscle actin. Group 3 consistently comprised tumours with the highest Ki-67 levels, EGFr positivity, and ER-PGR negative status. On the other hand, groups 1 and 2 usually exhibited a positive hormonal status, lower proliferative activity, and EGFr negativity. The results of this study indicate that the determination of IFPs can significantly contribute to the identification of groups of patients with different biopathological settings and possibly different clinical behaviour.
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Tumor diagnosis by intermediate filament typing: a novel tool for surgical pathology.
Mary Osborn, K. Weber · PubMed · 1983 · 871 citations