Salicylate‐Induced Malformations in Mouse Embryos¹

Abstract

Summary A single intramuscular injection of 10 mg of sodium salicylate was administered to pregnant mice of the A/Jax strain on one of the 7th to 13th days of gestation. A preliminary report is given of the gross anomalies observed in dissected‐out 18–day embryos. They consisted of severe disturbances in skeletal and vascular development. The embryos seemed to be most sensitive to injection given on the 12th and 13th days of gestation. The possible relation is discussed between development of these anomalies and inhibition of mucopolysaccharide synthesis by salicylates.