An improved and fully validated LC–MS/MS method for the simultaneous quantification of simvastatin and simvastatin acid in human plasma

The effects of sample preparation methods on the variability of the electrospray ionization response for model drug compounds

Ryan P. Bonfiglio, Richard C. King, Timothy Olah et al. · Rapid Communications in Mass Spectrometry · 1999 · 922 citations

Pharmacy, Pharmaceutical Analysis, Pharmaceutics +10

3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 4. Side-chain ester derivatives of mevinolin

William F. Hoffman, Alfred W. Alberts, Paul Anderson et al. · Journal of Medicinal Chemistry · 1986 · 266 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13

Metabolic disposition studies on simvastatin, a cholesterol-lowering prodrug.

S. Vickers, C A Duncan, I W Chen et al. · Drug Metabolism and Disposition · 1990 · 245 citations

Pharmacy, Pharmacokinetics, Pharmacology +17

In vitro and in vivo biotransformation of simvastatin, an inhibitor of HMG CoA reductase.

S. Vickers, C A Duncan, Kamlesh P. Vyas et al. · Drug Metabolism and Disposition · 1990 · 154 citations

Life Sciences, Biochemistry, Pharmacology +13

Direct-injection LC–MS–MS method for high-throughput simultaneous quantitation of simvastatin and simvastatin acid in human plasma

Mohammed Jemal, Zheng Ouyang, Mark L. Powell · Journal of Pharmaceutical and Biomedical Analysis · 2000 · 113 citations

Pharmacy, Pharmaceutical Analysis, Pharmacology +6