Maturation of sympathicoblastoma into ganglioneuroma.Report of 2 patients with 20- and 46-year survivals respectively

Abstract

of this paper is to report on 2 T patients who had sympathicoblastoma or neuroblastoma in early childhood and have survived for 20 and 46 years respectively. In each case, the tumor exhibited the phenomenon of maturation into a ganglioneuroma. The first of these cases-that of P.W., a 20- year-old man-has not previously been fully reported. The patient has been mentioned in reports describing the treatment of malignant tumors with Coley's toxin, in a report by Stewart' on his experiences with spontaneous regression of tumors, and in Phillip's report6 on neuroblastoma. The second case-that of W.W., a 48-year-old man-was previously reported by Cushing and Wolbach in 1927.2 This is the most frequently quoted reference to spontaneous maturation of a neuroblastoma into a benign ganglioneuroma. This patient had been followed for 16 years when first reported on; more recent examination and study of the patient adds an additional 30 years of follow-up.