Iron‐Catalyzed Enantioselective Hydrosilylation of Ketones

Abstract

Reductions under iron rule: Enantioselective hydrosilylation of prochiral ketones with inexpensive and environmentally benign iron catalysts proceed smoothly in the presence of (S,S)-Me-duphos (see scheme; (S,S)-Me-duphos=1,2-(bis[(2S,5S)]-2,5-dimethylphospholano)benzene). A broad range of aryl ketones is converted into the corresponding secondary alcohols in up to 99 % enantioselectivity and quantitative yields.