SIAM Journal on Applied Mathematics · 1994 · 182 citations · 15 references
Natural SciencesBiophysicsMathematicsDifferential EquationsDynamical SystemsNeurobiophysicsBoundary-layer TheoryBoundary-value ProblemsDifference EquationsMembrane PotentialPerturbation TheorySingular Perturbation TheoryBoundary Layer BehaviorBoundary-layer EquationsLaplace TransformLaplace Transforms Of Differential EquationsLinear Difference EquationsSecond-order Differential EquationsSingular Perturbation AnalysisSingularly Perturbed Boundary Value Problems
In this paper, an investigation is initiated of boundary-value problems for singularly perturbed linear second-order differential-difference equations with small shifts, i.e., where the second-order derivative is multiplied by a small parameter and the shift depends on the small parameter. Similar boundary-value problems are associated with expected first-exit times of the membrane potential in models for neurons. In particular, this paper focuses on problems with solutions that exhibit layer behavior at one or both of the boundaries. The analyses of the layer equations using Laplace transforms lead to novel results. It is shown that the layer behavior can change its character and even be destroyed as the shifts increase but remain small. In the companion paper [SIAM J. Appi. Math., 54 (1994), pp. 273–283], similar boundary-value problems with solutions that exhibit rapid oscillations are studied.
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Introduction to Singular Perturbations
Wolfgang Wasow, Robert E. O’Malley · Mathematics of Computation · 1975 · 955 citations
A Theoretical Analysis of Neuronal Variability
Richard B. Stein · Biophysical Journal · 1965 · 750 citations · Full text