Diagnostic efficacy of ischemia modified albumin and its correlation with lipid profile, oxidative stress in acute myocardial infarct patients on admission

Abstract

To evaluate the diagnostic efficacy of ischemia modified albumin (IMA) and its correlation with lipid profile, oxidative stress in acute myocardial infarct (AMI) patients attending Cardiology Emergency Department (ED). At presentation serum IMA in conjunction with electrocardiogram (ECG) and cardiac troponin T (CTnT) was evaluated in 35 AMI patients attending the ED within 6 hours of chest pain. These patients were subjected to standardized diagnostic procedures and treatment. Thirty five healthy volunteers were enrolled as control. IMA showed a higher level in ischemic patients than in control with the highest sensitivity (77%) in comparison to CTnT and ECG. With CTnT or ECG, IMA documented a sensitivity of 83% and 88%, respectively. Whereas with both CTnT and ECG, IMA identified 94% of AMI patients with the highest negative predictive value (90%). IMA has evolved as a cost effective, highly sensitive, early diagnostic marker of cardiac ischemia and an earlier rule out test in AMI patients.