17-KETOSTEROID FRACTIONATION STUDIES BY A MICRO-CHROMATOGRAPHIC TECHNIQUE IN ENDOCRINE DISORDERS

Abstract

SUMMARY Urinary 17-ketosteroids have been fractionated by adsorption chromatography on alumina into eight fractions, the main constituents of which are described. The patterns of 17-ketosteroid excretion in patients with various forms of endocrine disorder have been compared with those from normal subjects. The value of this investigation in clinical medicine is discussed. Although not of diagnostic importance, it is of use in the assessment of two aspects of adrenocortical activity, the excretion of the β-hydroxy-17-ketosteroids and the 11-oxy-17-ketosteroids.