Effect of analogues of steroid and thyroxine hormones on wound healing in hamsters

Abstract

The effect of two anabolic hormones on wound healing was studied. Following the extraction of a lower first molar, ten normal hamsters received intraperitoneal injections of Durabolin, ten received Synthroid, and ten were given Durabolin and Synthroid. Ten controls received saline injections. Two animals from each group were sacrificed at 4, 8, 12, 16, and 20 days post extraction. Histological sections revealed the following changes: Animals treated with Durabolin exhibited fewer inflammatory cells, significant earlier bone fill and more accelerated reepithelization than the controls. The group receiving Synthroid produced bone replacement earlier than the controls. Epithelization occurred at essentially the same rate. When Durabolin and Synthroid were administered simultaneously, the animals demonstrated fewer inflammatory cells and less bone fill than the controls.