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EFFECT OF THYROID STATUS ON THE THYROTROPHIN-RELEASING HORMONE-DEGRADING ACTIVITY OF RAT SERUM
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1976
Year
Endocrine MechanismMedicinePhysiologyThyroid DiseaseParathyroid HormoneThyroid DisordersParathyroid GlandMetabolismThyroid HormoneHuman SerumEndocrinologyPharmacologyTrh-degrading ActivityReproductive Endocrinology
The TRH-degrading activity of rat serum in vitro is five times more potent than that of human serum. In rats, it is significantly reduced in hypothyroidism (thiouracil-induced) and significantly increased in hyperthyroidism (T3 or T4-induced). This suggests a possible role in the regulation of adenohypophysial-thyroid function which is probably, in turn, dependent on thyroid hormone, rather than TSH, levels.