Journal of Endocrinology · 1976 · 41 citations · 0 references
Endocrine MechanismMedicinePhysiologyThyroid DiseaseParathyroid HormoneThyroid DisordersParathyroid GlandMetabolismThyroid HormoneHuman SerumEndocrinologyPharmacologyTrh-degrading ActivityReproductive Endocrinology
The TRH-degrading activity of rat serum in vitro is five times more potent than that of human serum. In rats, it is significantly reduced in hypothyroidism (thiouracil-induced) and significantly increased in hyperthyroidism (T3 or T4-induced). This suggests a possible role in the regulation of adenohypophysial-thyroid function which is probably, in turn, dependent on thyroid hormone, rather than TSH, levels.