Thiazolidinediones Downregulate Wnt/β-Catenin Signaling Via Multiple Mechanisms in Breast Cancer Cells

β-Catenin regulates expression of cyclin D1 in colon carcinoma cells

Osamu Tetsu, Frank McCormick · Nature · 1999 · 3.6K citations

Cancer Research, Oncology, Colon Carcinoma Cells +10

AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1

Seiji Satoh, Yataro Daigo, Yoichi Furukawa et al. · Nature Genetics · 2000 · 950 citations

Tumor Biology, Medicine, Growth Suppression +9

Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice

Ann Tsukamoto, Rudolf Grosschedl, Raphael C. Guzman et al. · Cell · 1988 · 747 citations

Knockout Mouse, Medicine, Mammary Gland +10

Wnt Proteins Prevent Apoptosis of Both Uncommitted Osteoblast Progenitors and Differentiated Osteoblasts by β-Catenin-dependent and -independent Signaling Cascades Involving Src/ERK and Phosphatidylinositol 3-Kinase/AKT

Maria Almeida, Han Li, Teresita Bellido et al. · Journal of Biological Chemistry · 2005 · 396 citations · Full text

Wnt-induced dephosphorylation of Axin releases beta -catenin from the Axin complex

Karl Willert, Sayumi Shibamoto, Roel Nusse · Genes & Development · 1999 · 338 citations · Full text

Lowers Axin, Wnt-induced Dephosphorylation, Cytoskeleton +18