Concepedia

Corticotropin Releasing Factor Decreases Postburst Hyperpolarizations and Excites Hippocampal Neurons

J. Aldenhoff, Donna L. Gruol, J. Rivier, Wylie Vale, G. R. Siggins

Science · 1983 · 314 citations · 16 references

DOI

Concepts

Abstract

Corticotropin releasing factor in concentrations of 15 to 250 nanomoles per liter increased the spontaneous discharge frequency and decreased the size of hyperpolarizations after burst discharges in CA1 and CA3 pyramidal neurons of rat hippocampal slices. Concentrations greater than 250 nanomoles per liter also depolarized the cells. These excitatory actions of corticotropin releasing factor may involve a novel calcium-dependent process.

References

16

Characterization of a 41-Residue Ovine Hypothalamic Peptide That Stimulates Secretion of Corticotropin and β-Endorphin

Joachim Spiess, Catherine Rivier · Science · 1981 · 4K citations

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Characterization of a 41-Residue Ovine Hypothalamic Peptide that Stimulates Secretion of Corticotropin and β-Endorphin

Wylie Vale, Joachim Spiess, Catherine Rivier et al. · Obstetrical & Gynecological Survey · 1982 · 3.9K citations

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Organization of Ovine Corticotropin-Releasing Factor Immunoreactive Cells and Fibers in the Rat Brain: An Immunohistochemical Study

L. W. Swanson, Paul E. Sawchenko, Jean Rivier et al. · Neuroendocrinology · 2008 · 2K citations

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Corticotropin releasing factor produces behavioural activation in rats

Richard E. Sutton, George F. Koob, Michel Le Moal et al. · Nature · 1982 · 760 citations

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Corticotropin-releasing factor activates noradrenergic neurons of the locus coeruleus

Rita J. Valentino, Stephen L. Foote, Gary Aston‐Jones · Brain Research · 1983 · 605 citations

, , +13