Science · 1969 · 2.1K citations · 75 references
Life SciencesCell BiologyGeneticsCell DifferentiationGene RegulationTranscriptional RegulationCell Differentiation ControlCell-type Specific Gene ExpressionDevelopmental Gene ExpressionGene Expression RegulationTranscription In EukaryotesTranscriptional Regulation In EukaryotesCell Type-specific Transcriptional RegulationCell-type Specific TranscriptionDevelopmental Gene RegulationRna-based Gene RegulationTranscriptional Control Of DifferentiationTranscriptional Regulation During DifferentiationTranscriptional Regulation Of Differentiation
Cell differentiation is based almost certainly on the regulation of gene activity, so that for each state of differentiation a certain set of genes is active in transcription and other genes are inactive. The establishment of this concept (1) has depended on evidence \nindicating that the cells of an organism generally contain identical genomes (2). Direct support for the idea that regulation of gene activity underlies cell differentiation \ncomes from evidence that much of the genome in higher cell \ntypes is inactive (3) and that different ribonucleic acids (RNA) are synthesized in different cell types (4).
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