Reduced Cyclic AMP Production in Fragile X Syndrome: Cytogenetic and Molecular Correlations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

Piotr Chomczyński, Nicoletta Sacchi · Analytical Biochemistry · 1987 · 46.8K citations

Engineering, Natural Sciences, Rna Isolation +7

Molecular basis of myotonic dystrophy: Expansion of a trinucleotide (CTG) repeat at the 3′ end of a transcript encoding a protein kinase family member

J. David Brook, Mila E. McCurrach, H G Harley et al. · Cell · 1992 · 2.8K citations

Signal Transduction, Mendelian Disorder, Genetic Disorder +7

Molecular Biology of Learning: Modulation of Transmitter Release

Eric R. Kandel, James H. Schwartz · Science · 1982 · 1.6K citations

Instability of a 550-Base Pair DNA Segment and Abnormal Methylation in Fragile X Syndrome

I. Oberlé, F. Rousseau, Dominique Heitz et al. · Science · 1991 · 1.5K citations

Phenotypic Expression, Epigenetic Change, Genetics +16

<i>FMR1</i> Protein: Conserved RNP Family Domains and Selective RNA Binding

Claude T. Ashley, Keith D. Wilkinson, Daniel Reines et al. · Science · 1993 · 733 citations

Fmr1 Protein, Engineering, Genetics +19