Biomacromolecules · 2007 · 90 citations · 17 references
MedicineMaterials ScienceOphthalmologyBiomaterialsOphthalmic SurgeryPolymer ChemistryCataract SurgeryLens PathologyLens SurgeryOcular ImplantsOphthalmic BiomaterialsSoft Contact LensesAttenuated Total ReflectanceOphthalmic Surface CoatingsOptical PropertiesPosterior Capsule OpacificationProtein Adsorption AnalysisSecondary CataractSurface Modification Of Ocular BiomaterialsSurface Optical Properties
Cataract surgery is a routine ophthalmologic intervention resulting in replacement of the opacified natural lens by a polymeric intraocular lens (IOL). A main postoperative complication, as a result of protein adsorption and lens epithelial cell (LEC) adhesion, growth, and proliferation, is the secondary cataract, referred to as posterior capsular opacification (PCO). To avoid PCO formation, a poly(ethylene glycol) (PEG) chemical coating was created on the surface of hydrogel IOLs. Attenuated total reflectance Fourier transform infrared spectroscopy, "captive bubble" and "water droplet" contact angle measurements, and atomic force microscopy analyses proved the covalent grafting of the PEG chains on the IOL surface while keeping unchanged the optical properties of the initial material. A strong decrease of protein adsorption and cell adhesion depending on the molar mass of the grafted PEG (1100, 2000, and 5000 g/mol) was observed by performing the relevant in vitro tests with green fluorescent protein and LECs, respectively. Thus, the study provides a facile method for developing materials with nonfouling properties, particularly IOLs.
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Stéphanie Pasche, Susan M. De Paul, János Vörös et al. · Langmuir · 2003 · 410 citations
Surface engineering strategies for control of protein and cell interactions
Nidhi Nath, Jinho Hyun, Hongwei Ma et al. · Surface Science · 2004 · 232 citations