Alterations in transformation efficiency by the ADPRT-inhibitor 3-aminobenzamide are oncogene specific

Abstract

The ADPRT inhibitor 3-aminobenzamide inhibits transformation of NIH 3T3 cells by the ras, v-src, v-mos and v-raf oncogenes. No effect was observed on transformation by v-fos while the transforming efficiency of SV40 DNA was increased approximately two-fold. The effect on the transformation by the ras gene occurs between days 3 and 7 of the transfection.