Penazetidine A, an alkaloid inhibitor of protein kinase C

Staurosporine, a potent inhibitor of phospholipidCa++dependent protein kinase

Tatsuya Tamaoki, Hisayo Nomoto, ISAMI TAKAHASHI et al. · Biochemical and Biophysical Research Communications · 1986 · 2.5K citations

Life Sciences, Biochemistry, Pharmacology +10

Penaresidin A and B, two novel azetidine alkaloids with potent actomyosin ATPase-activating activity from the Okinawan marine sponge Penares sp.

Jun’ichi Kobayashi, Jie‐Fei Cheng, Masami Ishibashi et al. · Journal of the Chemical Society Perkin Transactions 1 · 1991 · 131 citations

Life Sciences, Marine Biology, Marine Sciences +15

Transmembrane signaling by interferon alpha involves diacylglycerol production and activation of the epsilon isoform of protein kinase C in Daudi cells.

Lawrence M. Pfeffer, Barbara L. Eisenkraft, Nancy C. Reich et al. · Proceedings of the National Academy of Sciences · 1991 · 89 citations · Full text

Life Sciences, Biochemistry, Immunology +17

Marine sponge polyketide inhibitors of protein tyrosine kinase

Rita H. Lee, Doris L. Slate, Robert Moretti et al. · Biochemical and Biophysical Research Communications · 1992 · 73 citations

Natural Sciences, Marine Biology, Marine Sciences +14

11-Hydroxystaurosporine: a highly cytotoxic, powerful protein kinase C inhibitor from a tunicate

Robin B. Kinnel, Paul J. Scheuer · The Journal of Organic Chemistry · 1992 · 68 citations

Medicine, Medicinal Chemistry, Pharmacology +9