A Dicarboxylic Fatty Acid Derivative of Paclitaxel for Albumin-Assisted Drug Delivery

Phase III Trial of Nanoparticle Albumin-Bound Paclitaxel Compared With Polyethylated Castor Oil–Based Paclitaxel in Women With Breast Cancer

William J. Gradishar, Sergei Tjulandin, Neville Davidson et al. · Journal of Clinical Oncology · 2005 · 2.1K citations · Full text

Pharmacy, Oncology, Pharmacology +15

Increased antitumor activity, intratumor paclitaxel concentrations, and endothelial cell transport of cremophor-free, albumin-bound paclitaxel, ABI-007, compared with cremophor-based paclitaxel.

Neil Desai, Vuong Trieu, Zhiwen Yao et al. · Clinical Cancer Research · 2006 · 1.2K citations

Medicine, Oncology, Pharmacology +14

Comparative Preclinical and Clinical Pharmacokinetics of a Cremophor-Free, Nanoparticle Albumin-Bound Paclitaxel (ABI-007) and Paclitaxel Formulated in Cremophor (Taxol)

Alex Sparreboom, Charity D. Scripture, Vuong Trieu et al. · Clinical Cancer Research · 2005 · 496 citations · Full text

Pharmacy, Clinical Pharmacokinetics, Pharmacology +17

Location of High and Low Affinity Fatty Acid Binding Sites on Human Serum Albumin Revealed by NMR Drug-competition Analysis

Jeffrey R. Simard, Patricia A. Zunszain, James A. Hamilton et al. · Journal of Molecular Biology · 2006 · 342 citations

Life Sciences, Biochemistry, Pharmaceutics +9

Albumin binding of insulins acylated with fatty acids: characterization of the ligand-protein interaction and correlation between binding affinity and timing of the insulin effect <i>in vivo</i>

Peter Kurtzhals, Svend Havelund, Inge Jonassen et al. · Biochemical Journal · 1995 · 329 citations · Full text

Life Sciences, Biochemistry, Endocrinology +17