Journal of Biomolecular Structure and Dynamics · 1986 · 180 citations · 14 references
Life SciencesEvolutionary BiologyLinguisticsComparative GenomicsMolecular EvolutionMorphologyDna SequencingMorphological AnalysisMorphological ComparisonPhylogenomic AnalysisSequence AlignmentSequence AnnotationLinguistic PhylogeneticsSequence Similarity
The concept of "words" in continuous languages devoid of blanks is introduced and an operational definition of words given. With this novel concept nucleotide sequences become object for linguistic analysis. The typical word size of the nucleotide language is found to be 3 to 5 (tri- to pentamers). Different genomes have distinct vocabularies. Comparison of these vocabularies can serve as a basis for revealing functional and evolutionary relatedness of sequences.
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Nucleotide sequence of bacteriophage λ DNA
Frederick Sanger, Alan Coulson, G. F. Hong et al. · Journal of Molecular Biology · 1982 · 1.2K citations
Genome structure described by formal languages
Volker Brendel, H. G. Busse · Nucleic Acids Research · 1984 · 87 citations · Full text
A Vector for Introducing New Genes into Plants
Mary-Dell Chilton · Scientific American · 1983 · 71 citations