THE EFFECT OF TESTOSTERONE PROPIONATE UPON INCORPORATION OF LABELED GLYCINE INTO MOUSE KIDNEY SLICES12

Abstract

ONE of the characteristic properties of androgenic steroids generally is their ability to promote protein synthesis in certain tissues other than those of the male reproductive tract. The gross manifestations of this anabolic property have been described in detail (cf. 1). However, detailed knowledge of the mechanisms involved is almost totally lacking. Selection of in vitro incorporation studies as a tool for the investigation of this problem is based upon repeated observations that a direct correspondence exists between the rate at which labeled amino acids are incorporated into protein in vitro and increased protein anabolic activity in various physiological situations. Thus, increased incorporation rates are well known to characterize rapidly growing foetal or regenerating adult liver.