Science · 1983 · 23 citations · 18 references
MedicineNeurosciencePharmacologyBehavioral NeuroscienceBehavioral PharmacologyRadiobiologyBehavioral PhysiologyNeuroendocrine Integration Of BehaviorNeuroendocrine PharmacologyOpioid AnalgesicsOpioid PharmacologyRadiation PhysiologyBehavioral PharmacodynamicsEndogenous Opioid ModulationEndogenous Opioid SignalingEndogenous OpioidsOpioid Pharmacodynamics
Exposure of C57BL/6J mice to ionizing radiation caused stereotypical locomotor hyperactivity similar to that produced by morphine. Naloxone administration prevented this radiation-induced behavioral activation. These results support the hypothesis that endorphins are involved in some aspects of radiogenic behavioral change.
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Opiates and endogenous opioid peptides
John Kelly, Raymond Dingledine · Trends in Biochemical Sciences · 1977 · 1.3K citations
Medicine, Neuroscience, Pharmacology +12
Opioid and Nonopioid Mechanisms of Stress Analgesia
James W. Lewis, J. Timothy Cannon, John C. Liebeskind · Science · 1980 · 749 citations