Horner–Wadsworth–Emmons Reaction of Unprotected Sugars in Water or in the Absence of Any Solvent: One‐Step Access to <i>C</i>‐Glycoside Amphiphiles

Abstract

Abstract The synthesis of C ‐glycosides in water or in the absence of any solvent from free sugars and β‐keto phosphonates is reported. The methodology permits a one‐step access to C ‐glycoside amphiphiles in moderate‐to‐good yields. The selectivity (α/β and furanoside/pyranoside) is discussed and a process that leads to pure β‐ C ‐pyranosides is also described.