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Isocytosine-based inhibitors of xanthine oxidase: Design, synthesis, SAR, PK and in vivo efficacy in rat model of hyperuricemia

Smriti Khanna, Sandeep Burudkar, Komal Bajaj, Pranay Shah, Ashish P. Keche, Usha Ghosh, Avani Desai, Ankita Srivastava, Asha Kulkarni‐Almeida, Nitin Deshmukh,

Bioorganic & Medicinal Chemistry Letters · 2012 · 48 citations · 4 references

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Extra Precision Glide:  Docking and Scoring Incorporating a Model of Hydrophobic Enclosure for Protein−Ligand Complexes

Richard A. Friesner, Robert B. Murphy, Matthew P. Repasky et al. · Journal of Medicinal Chemistry · 2006 · 6.9K citations

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Y-700 [1-[3-Cyano-4-(2,2-dimethylpropoxy)phenyl]-1 H-pyrazole-4-carboxylic Acid]: A Potent Xanthine Oxidoreductase Inhibitor with Hepatic Excretion

Atsushi Fukunari, Ken Okamoto, Takeshi Nishino et al. · Journal of Pharmacology and Experimental Therapeutics · 2004 · 112 citations

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Identification of novel isocytosine derivatives as xanthine oxidase inhibitors from a set of virtual screening hits

Chandrika B‐Rao, Asha Kulkarni‐Almeida, Kamlesh V. Katkar et al. · Bioorganic & Medicinal Chemistry · 2012 · 56 citations · Full text

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New relief for gout

Jill Adams · Nature Biotechnology · 2009 · 14 citations

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