Concepedia

Celastrol suppresses breast cancer MCF-7 cell viability via the AMP-activated protein kinase (AMPK)-induced p53–polo like kinase 2 (PLK-2) pathway

Ji Hae Kim, Jung Ok Lee, Soo Kyung Lee, Nami Kim, Ga Young You, Ji Wook Moon, Jie Sha, Su Jin Kim, Sun Hwa Park, Hyeon Soo Kim

Cellular Signalling · 2012 · 64 citations · 20 references

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20

Surfing the p53 network

Bert Vogelstein, David P. Lane, Arnold J. Levine · Nature · 2000 · 6.6K citations

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Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators

Haley Hieronymus, Justin Lamb, Kenneth N. Ross et al. · Cancer Cell · 2006 · 627 citations · Full text

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Celastrol, a Triterpene Extracted from the Chinese “Thunder of God Vine,” Is a Potent Proteasome Inhibitor and Suppresses Human Prostate Cancer Growth in Nude Mice

Huanjie Yang, Di Chen, Qiuzhi Cindy Cui et al. · Cancer Research · 2006 · 585 citations

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A novel Hsp90 inhibitor to disrupt Hsp90/Cdc37 complex against pancreatic cancer cells

Tao Zhang, Adel Hamza, Xianhua Cao et al. · Molecular Cancer Therapeutics · 2008 · 368 citations · Full text

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Celastrol, a novel triterpene, potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting NF-κB–regulated gene products and TAK1-mediated NF-κB activation

Gautam Sethi, Kwang Seok Ahn, Manoj K. Pandey et al. · Blood · 2006 · 340 citations · Full text

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