The transplacental transfer of the macrolide antibiotics erythromycin, roxithromycin and azithromycin

Abstract

The limited transplacental transfer of erythromycin, roxithromycin and azithromycin suggests compromised efficacy in the treatment of fetal infections. On the other hand, the placenta seems to produce an effective barrier reducing the fetal exposure when these three macrolides are used to treat maternal infections.