Association of Polymorphisms in the Interleukin-18 Gene in Patients With Crohnʼs Disease Depending on the CARD15/NOD2 Genotype

Abstract

In this study, significant differences of several genotypes and diplotypes within the IL-18 gene in CD depending on CARD15/NOD2 status have been found. In context with an increased expression of IL-18 in CD, it remains to be shown whether the expression of IL-18 is influenced by CARD15/NOD2 mutation status.