Labeling, detection and identification of newly synthesized proteomes with bioorthogonal non-canonical amino-acid tagging

A Stepwise Huisgen Cycloaddition Process: Copper(I)-Catalyzed Regioselective “Ligation” of Azides and Terminal Alkynes

Vsevolod V. Rostovtsev, Luke G. Green, Valery V. Fokin et al. · Angewandte Chemie International Edition · 2002 · 11.4K citations

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Probability-based protein identification by searching sequence databases using mass spectrometry data

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An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database

Jimmy K. Eng, Ashley L. McCormack, John R. Yates · Journal of the American Society for Mass Spectrometry · 1994 · 6.6K citations

Biological Mass Spectrometry, Molecular Biology, Protein Analysis +24

Stable Isotope Labeling by Amino Acids in Cell Culture, SILAC, as a Simple and Accurate Approach to Expression Proteomics

Shao‐En Ong, Blagoy Blagoev, Irina Kratchmarova et al. · Molecular & Cellular Proteomics · 2002 · 5.6K citations · Full text

Empirical Statistical Model To Estimate the Accuracy of Peptide Identifications Made by MS/MS and Database Search

Andrew Keller, Alexey I. Nesvizhskii, Eugene Kolker et al. · Analytical Chemistry · 2002 · 4.9K citations

Engineering, Computed Probabilities, Information Retrieval +22