Cyclophosphamide-Associated Leukemia in Wegener's Granulomatosis

Abstract

Brief Reports1 March 1981Cyclophosphamide-Associated Leukemia in Wegener's GranulomatosisGARY E. WHEELER, M.D.GARY E. WHEELER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-94-3-361 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe efficacy of cyclophosphamide therapy in Wegener's granulomatosis is well established. Recent reports have suggested other vasculitides may also be responsive to this drug (1, 2). Long-term follow-up studies of patients with Wegener's granulomatosis have not found significant toxicity from continuous cyclophosphamide therapy (3, 4). A patient with Wegener's granulomatosis in whom the development of acute leukemia appears related to cyclophosphamide therapy is described here.A 53-year-old woman was seen in November 1978 with a 6-week history of arthritis of the second proximal interphalangeal joint of the left hand, the third proximal interphalangeal joint of the right foot, a 7.7...References1. FAUCIHAYNESKATZ ABP. The spectrum of vasculitis: clinical, pathologic, immunologic, and therapeutic considerations. Ann Intern Med. 1978;89:660-76. LinkGoogle Scholar2. FAUCIKATZHAYNESWOLFF APBS. Cyclophosphamide therapy of severe systemic necrotizing vasculitis. N Engl J Med. 1979;301:235-8. CrossrefMedlineGoogle Scholar3. WOLFFFAUCIHORNDALE SARD. Wegener's granulomatosis. Ann Intern Med. 1974;81:513-25. LinkGoogle Scholar4. REZADORNFELDGOLDBERGBLUESTONEPEARSON MLLRC. Wegener's granulomatosis: long-term followup of patients treated with cyclophosphamide. Arth Rheum. 1975;18:501-6. CrossrefMedlineGoogle Scholar5. WESTBERGSWOLIN NB. Acute myeloid leukemia appearing in two patients after prolonged continuous chlorambucil treatment for Wegener's granulomatosis. Acta Med Scand. 1976;199:373-7. CrossrefMedlineGoogle Scholar6. CHANGGEARY JC. Therapy-linked leukemia. Lancet. 1977;1:97. Letter. CrossrefMedlineGoogle Scholar7. GOLDE D. Pathogenesis of acute myeloid leukemia, pp. 758-9. In: CLINE MJ, moderator. Acute leukemia: biology and treatment. Ann Intern Med. 1979;91:758-73. MedlineGoogle Scholar8. CASCIATOSCOTT DJ. Acute leukemia following prolonged cytotoxic agent therapy. Medicine (Baltimore). 1979;58:32-47. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited BySquamous cell carcinoma of the nasal septum with Wegener's granulomatosis treated with cyclophosphamide and corticosteroidsMyelodysplastic syndrome after cisplatin therapyTherapy-related leukaemia in Wegener's granulomatosisStage-adapted treatment of Wegener's granulomatosisCyclophosphamide in the Treatment of Orbital VasculitisMechanisms of Action and Clinical Applications of Cytotoxic Drugs in Rheumatic DisordersTOXIC OIL SYNDROME AND GRAFT-VERSUS-HOST DISEASECYTOTOXIC THERAPY FOR WEGENER'S GRANULOMATOSISDiffuse histiocytic lymphoma in a patient treated with cyclophosphamide for Wegener's granulomatosisCarcinogenicity of antineoplastic agents in manWegener's granulomatosis in childhood: Cutaneous manifestations as the presenting signsWegener's granulomatosis: First report of a case with onset during pregnancyWegener's Granulomatosis: Prospective Clinical and Therapeutic Experience With 85 Patients for 21 YearsANTHONY S. FAUCI, M.D., BARTON F. HAYNES, M.D., PAUL KATZ, M.D., SHELDON M. WOLFF, M.D.Cytostatic and immunosuppressive drugsCytotoxic Drugs for Nephrotic SyndromeTherapeutic workshop on modifying the disease process in rheumatoid arthritis: immunosuppression in perspective.References 1 March 1981Volume 94, Issue 3Page: 361-362KeywordsArthritisCyclophosphamideDrugsToxicityVasculitisWegener granulomatosis Issue Published: 1 March 1981 PDF DownloadLoading ...