The solid phase synthesis of complex propargylamines using the combination of sonogashira and mannich reactions

A convenient synthesis of acetylenes: catalytic substitutions of acetylenic hydrogen with bromoalkenes, iodoarenes and bromopyridines

Kenkichi Sonogashira, Yasuo Tohda, Nobue Hagihara · Tetrahedron Letters · 1975 · 5.1K citations

Chemical Engineering, Catalytic Substitutions, Engineering +8

Color test for detection of free terminal amino groups in the solid-phase synthesis of peptides

E. T. Kaiser, Robert L. Colescott, C.D. Bossinger et al. · Analytical Biochemistry · 1970 · 3.5K citations

Protein Chemistry, Solid-phase Synthesis, Biochemistry +10

Combinatorial chemistry, synthesis and application

European Journal of Medicinal Chemistry · 1997 · 231 citations

Combinatorial Chemistry, Natural Sciences, Diversity-oriented Synthesis +2

Rapid Solution and Solid Phase Syntheses of Oligo(1,4-phenylene ethynylene)s with Thioester Termini:  Molecular Scale Wires with Alligator Clips. Derivation of Iterative Reaction Efficiencies on a Polymer Support

LeRoy Jones, Jeffry S. Schumm, James M. Tour · The Journal of Organic Chemistry · 1997 · 213 citations

Engineering, Organic Chemistry, Chemistry +20

Solid-phase synthesis of indoles using the palladium-catalysed coupling of alkynes with iodoaniline derivatives

Maria Chiara Fagnola, Ilaria Candiani, Giuseppina Visentin et al. · Tetrahedron Letters · 1997 · 112 citations

Chemical Engineering, Palladium-catalysed Coupling, Solid-phase Synthesis +10