Identification of rate-limiting steps in cephalosporin C biosynthesis in Cephalosporium acremonium: a theoretical analysis

Numerical Initial Value Problems in Ordinary Differential Equations

E. I., C. W. Gear · Mathematics of Computation · 1973 · 4K citations

Natural Sciences, Mathematics, Physics +12

Enzyme kinetics; behavior and analysis of rapid equilibrium and steady state enzyme systems

International Journal of Biochemistry · 1994 · 3K citations

Life Sciences, Biochemistry, Chemistry +16

A Linear Steady-State Treatment of Enzymatic Chains. Critique of the Crossover Theorem and a General Procedure to Identify Interaction Sites with an Effector

Reinhart Heinrich, Tom A. Rapoport · European Journal of Biochemistry · 1974 · 242 citations · Full text

Life Sciences, Biochemistry, Enzymology +15

Isolation, sequence determination and expression in Escherichia coli of the isopenicillin N synthetase gene from Cephalosporium acremonium

Suellen M. Samson, Rama M. Belagaje, Dale T. Blankenship et al. · Nature · 1985 · 225 citations

Life Sciences, Microbiology, Molecular Biology +14

Cephalosporin C, a New Antibiotic containing Sulphur and D-α-Aminoadipic Acid

G. G. F. Newton, E. P. Abraham · Nature · 1955 · 210 citations

Pharmacy, Medicinal Chemistry, Pharmacology +6